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Home - Products - Endocrinology/Hormones - Estrogen Receptor/ERR - Endoxifen (E-isomer)

Endoxifen (E-isomer)

CAS No. 114828-90-9

Endoxifen (E-isomer)( E-Endoxifen | Endoxifen E-isomer )

Catalog No. M26199 CAS No. 114828-90-9

Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen. Endoxifen E-isomer has antiestrogenic effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Endoxifen (E-isomer)
  • Note
    Research use only, not for human use.
  • Brief Description
    Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen. Endoxifen E-isomer has antiestrogenic effects.
  • Description
    Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen. Endoxifen E-isomer has antiestrogenic effects.(In Vitro):Endoxifen exists as the potently anti-estrogenic (Z)-isomer and the lesser-known (E)-isomer. (E)-Endoxifen is identified as the primary degradant. The (E)-isomer is an impurity in (Z)-Endoxifen drug substance and increases under certain storage conditions.
  • In Vitro
    Endoxifen E-isomer (1-1000 nM; 12 h) inhibits PGR gene expression in E2-induced MCF-7 cells.
  • In Vivo
    ——
  • Synonyms
    E-Endoxifen | Endoxifen E-isomer
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    PEGs
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    114828-90-9
  • Formula Weight
    373.49
  • Molecular Formula
    C25H27NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (133.87 mM)
  • SMILES
    OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.An S, et al. Small-molecule PROTACs:An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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